InterPro domain: IPR009457

This domain is found in plant proteins including THH1/TOM1/TOM3 from Arabidopsis. TOM1 and TOM3 are transmembrane proteins necessary for the efficient multiplication of tobamoviruses [ 1 ]. THH1 supports tobamovirus multiplication, but to a lesser extent than TOM1 and TOM3 [ 2 ]. Members containing this domain are part of the GPCR superfamily and involved in stress tolerance [ 3 , 4 ].

1. Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes. J. Virol. 76, 2491-7
2. Involvement of THH1, an Arabidopsis thaliana homologue of the TOM1 gene, in tobamovirus multiplication. J. Gen. Virol. 87, 2397-401
3. A Novel G-Protein-Coupled Receptors Gene from Upland Cotton Enhances Salt Stress Tolerance in Transgenic Arabidopsis. Genes (Basel) 9
4. Genome-wide analysis of the cotton G-coupled receptor proteins (GPCR) and functional analysis of GTOM1, a novel cotton GPCR gene under drought and cold stress. BMC Genomics 20, 651