InterPro domain: IPR009413
General Information
- Identifier IPR009413
- Description Hemolysin, aegerolysin type
- Number of genes 16
- Gene duplication stats Loading...
- Associated GO terms GO:0019836
Abstract
This family consists of several bacterial and eukaryotic Aegerolysin-like proteins. Aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies, and these haemolysins may play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during sporulation [ 1 ]. Ostreolysin was found cytolytic to various erythrocytes and tumour cells [ 2 ]. It forms transmembrane pores 4 nm in diameter. Its activity is inhibited by total membrane lipids, and modulated by lysophosphatides.
1. Pleurotus and Agrocybe hemolysins, new proteins hypothetically involved in fungal fruiting. Biochim. Biophys. Acta 1570, 153-9
2. Temporal and spatial expression of ostreolysin during development of the oyster mushroom (Pleurotus ostreatus). Mycol. Res. 109, 377-82