InterPro domain: IPR009269

This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. It is the HDAC3 binding domain required for transcriptional repression [ 1 ]. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency [ 2 , 2 , 3 ].

1. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. Immunity 30, 696-707
2. NKAP is required for T cell maturation and acquisition of functional competency. J. Exp. Med. 208, 1291-304
3. The transcriptional repressor NKAP is required for the development of iNKT cells. Nat Commun 4, 1582