InterPro domain: IPR009241

General Information

  • Identifier IPR009241
  • Description Toxin HigB-like
  • Number of genes 1
  • Gene duplication stats Loading...

Abstract

This entry consists of putative toxins, including probable endoribonuclease HigB1 [ 1 ]. HigB1 is a toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) module. Upon expression in M.smegmatis it inhibits colony formation and cell growth [ 2 , 3 ].


1. Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Mol. Microbiol. 90, 195-207
2. Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 5, e1000767

Species distribution

Gene table