InterPro domain: IPR009212
General Information
- Identifier IPR009212
- Description Methylthioribose kinase
- Number of genes 150
- Gene duplication stats Loading...
- Associated GO terms GO:0009086 GO:0046522
Abstract
Members of this family are 5-methylthioribose kinases ( 2.7.1.100 ) that catalyse phosphorylation of 5-methylthioribose (MTR), a step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis. The preceding step of methylthioadenosine (MTA) hydrolysis to MTR is catalysed by 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase.
Bacillus subtilis protein MtnK (formerly YkrT) [ 1 ] and Klebsiella pneumoniae protein MtrK [ 2 ] have been experimentally characterised. K. pneumoniae MtrK expression is regulated by methionine [ 3 ].
As this enzyme is absent in mammals, it has been considered a target for rational drug design.
1. MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis. BMC Microbiol. 1, 15
2. Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae [corrected] Biochem. J. 317 ( Pt 1), 285-90
3. Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae. J. Gen. Microbiol. 139, 1027-31