InterPro domain: IPR009210

This entry represents activating signal cointegrator 1 complex subunit 1 (ASCC1, or ASC-1 complex subunit p50). In humans ASSC1 is part of the ASC-1 complex, consists of ASC-1, P200, P100, and P50. ASC-1 complex serves as a transcription coactivator molecule of nuclear receptors [ 1 ]. Human ASC-1 complex seems to play an essential role in AP-1, SRF, and NF-kappaB transactivation [ 2 ].

This entry also include some uncharacterised proteins from fungi (such as C15D4.13c from S. pombe).

1. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol. Cell. Biol. 19, 6323-32
2. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol. Cell. Biol. 22, 5203-11