InterPro domain: IPR009045

General Information

  • Identifier IPR009045
  • Description Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
  • Number of genes 3
  • Gene duplication stats Loading...

Abstract

The structure of the N-terminal signalling domain of hedgehog proteins has been solved and reveals a tetrahedrally coordinated zinc ion that is structurally homologous to the zinc-binding motif in bacterial D-alanyl-D-alanine carboxypeptidases (DD-peptidases) [ 1 ].


1. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature 378, 212-6

Species distribution

Gene table