InterPro domain: IPR009014

Transketolase C-terminal-like domains [ 1 ] can be found in a number of different enzymes, including the C-terminal domain of the pyruvate dehydrogenase E1 component [ 2 ], the C-terminal domain of branched-chain alpha-keto acid dehydrogenases [ 3 ], and domain II of pyruvate-ferredoxin oxidoreductase (PFOR) [ 4 ]. Structural studies reveal this domain to comprise of three layers alpha/beta/alpha. The mixed beta sheet consists of five strands in the order 13245, where strand 1 is antiparallel to the others. This domain has been proposed as a regulatory molecule binding site in transketolase [ 5 ].

1. Refined structure of transketolase from Saccharomyces cerevisiae at 2.0 A resolution. J. Mol. Biol. 238, 387-404
2. Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Biochemistry 41, 5213-21
3. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat. Struct. Biol. 6, 785-92
4. Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase. Science 294, 2559-63
5. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. EMBO J. 11, 2373-9