InterPro domain: IPR008895

This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin [ 1 ]. It is also required for vacuolar protein sorting in budding yeasts [ 2 ].

The Vps72 homologue from flies, YL-1, is part of the Tip60 chromatin-remodelling complex which is involved in DNA repair [ 2 ].

1. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science 340, 195-9
2. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306, 2084-7