InterPro domain: IPR008856
General Information
- Identifier IPR008856
- Description Translocon-associated protein subunit beta
- Number of genes 25
- Gene duplication stats Loading...
- Associated GO terms GO:0016021 GO:0005783
Abstract
This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion [ 1 ].
1. The Translocon-Associated Protein beta (TRAPbeta) in zebrafish embryogenesis. I. Enhanced expression of transcripts in notochord and hatching gland precursors. Mol. Cell. Biochem. 215, 93-101