InterPro domain: IPR008826

This family consists of selenium binding proteins from eukaryotes, bacteria and archaea. Human selenium-binding protein 1 (SELENBP1) is a methanethiol oxidase (MTO) that converts methanethiol to H2O2, formaldehyde, and H2S [ 1 ]. Bovine SBP56 has been shown to participate in late stages of intra-Golgi protein transport [ 2 ]. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role, and can be implicated in controlling the oxidation/reduction status of target proteins in vesicular Golgi transport [ 3 ].

1. Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. Nat. Genet. 50, 120-129
2. A 56-kDa selenium-binding protein participates in intra-Golgi protein transport. J. Biol. Chem. 275, 14457-65
3. Lotus japonicus gene Ljsbp is highly conserved among plants and animals and encodes a homologue to the mammalian selenium-binding proteins. Mol. Plant Microbe Interact. 15, 313-22