InterPro domain: IPR008814
General Information
- Identifier IPR008814
- Description Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1
- Number of genes 188
- Gene duplication stats Loading...
- Associated GO terms GO:0008250 GO:0016021 GO:0006487
Abstract
Swp1 is an essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyses the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [ 1 ]. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity [ 2 ].
1. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides. J. Biol. Chem. 269, 12908-17
2. Subunits of the translocon interact with components of the oligosaccharyl transferase complex. J. Biol. Chem. 280, 22917-24