InterPro domain: IPR008685

Kinetochores are the chromosomal sites for spindle interaction and play a vital role for chromosome segregation. Fission Saccharomyces cerevisiae kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length [ 1 ]. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants [ 2 ]. It has been shown that Mis12 might genetically interact with Mal2p [ 2 ].

1. Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev. 13, 1664-77
2. The mal2p protein is an essential component of the fission yeast centromere. Mol. Cell. Biol. 22, 7168-83