InterPro domain: IPR008672

General Information

  • Identifier IPR008672
  • Description Spindle assembly checkpoint component Mad1
  • Number of genes 130
  • Gene duplication stats Loading...
  • Associated GO terms GO:0007094  

Abstract

This family consists of pindle assembly checkpoint protein Mad1. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in Saccharomyces cerevisiae and higher eukaryotes. In Saccharomyces cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated [ 1 ].


1. Mad2 phosphorylation regulates its association with Mad1 and the APC/C. EMBO J. 22, 797-806

Species distribution

Gene table