InterPro domain: IPR008590

General Information

  • Identifier IPR008590
  • Description Transmembrane protein 230/134
  • Number of genes 311
  • Gene duplication stats Loading...

Abstract

This entry represents the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2 [ 1 ]. TMEM 230 is involved in trafficking and recycling of synaptic vesicles [ 2 ].


1. Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway. Virus Res. 228, 102-108
2. Identification of TMEM230 mutations in familial Parkinson's disease. Nat Genet 48, 733-9

Species distribution

Gene table