InterPro domain: IPR008521

General Information

  • Identifier IPR008521
  • Description Magnesium transporter NIPA

Abstract

NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters [ 1 , 2 ]. This entry also includes a group of uncharacterised bacterial proteins, such as Cgl0250 (UniProt:P42459) from Corynebacterium glutamicum.


1. NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter. J. Biol. Chem. 282, 8060-8
2. Functional characterization of NIPA2, a selective Mg2+ transporter. Am. J. Physiol., Cell Physiol. 295, C944-53

Species distribution

Gene table