InterPro domain: IPR008491

CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controlling cell proliferation [ 1 , 2 ]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [ 3 , 4 ]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [ 5 , 6 ]. It has been shown to bind Wip1 and stimulates its phosphatase activity [ 7 ].

1. A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. Biochem. Biophys. Res. Commun. 294, 161-6
2. Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. Cell Res. 13, 83-91
3. LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12, 239-51
4. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J. Biol. Chem. 285, 15126-36
5. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. J. Biol. Chem. 280, 20651-9
6. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. Cell Res. 19, 458-68
7. LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle 16, 213-223