InterPro domain: IPR008441

This entry consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae. This family is often transcribed with putative glycosyl transferases to give rise to bifunctional proteins [ 1 ]. O-glycosyltransferase PaGT from the yeast Phomopsis amygdali is important for the biosynthesis of the mycotoxins known as fusicoccins, diterpene glucosides which are potent activators of plasma membrane H+-ATPases in plants leading to constriction canker [ 2 ]. Glycosyltransferase afumC from Aspergillus fumigatus is part of the gene cluster that mediates the biosynthesis fumihopaside A, a hopane-type glucoside that enhances the thermotolerance and UV resistance [ 3 ]. Also included in this entry is the probable glycosyltransferase FCK3, which is part of the gene cluster that mediates the biosynthesis of cytokinins such as fusatin, fusatinic acids or 8-oxofusatin, known for their growth promoting and anti-senescence activities toward host plants [ 4 ].

1. Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters. Infect. Immun. 69, 1244-55
2. Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery. PLoS ONE 7, e42090
3. Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus. Org Lett 21, 3252-3256
4. The cereal pathogen Fusarium pseudograminearum produces a new class of active cytokinins during infection. Mol Plant Pathol 19, 1140-1154