InterPro domain: IPR008409

Proteins in this family are involved in mRNA splicing [ 1 ]. This family includes pre-mRNA-splicing factor SPF27, SNT309 and Cwf7. In humans, SPF27 is a component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. It may have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex [ 2 ].

1. Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms. Genes Dev. 21, 1484-93
2. Molecular architecture of the human Prp19/CDC5L complex. Mol. Cell. Biol. 30, 2105-19