InterPro domain: IPR008333
General Information
- Identifier IPR008333
- Description Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
- Number of genes 603
- Gene duplication stats Loading...
Abstract
These sequences represent the FAD-binding domain found in NADH:cytochrome b5 reductases and nitrate reductases.
To date, the 3D-structures of the flavoprotein domain of Zea mays (Maize) nitrate reductase [ 1 ] and of pig NADH:cytochrome b5 reductase [ 2 ] have been solved. The overall fold is similar to that of ferredoxin:NADP + reductase [ 3 ]: the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).
1. Crystal structure of the FAD-containing fragment of corn nitrate reductase at 2.5 A resolution: relationship to other flavoprotein reductases. Structure 2, 809-21
2. Crystal structure of NADH-cytochrome b5 reductase from pig liver at 2.4 A resolution. Biochemistry 34, 2763-7
3. Structure-function relations for ferredoxin reductase. J. Bioenerg. Biomembr. 26, 89-99