InterPro domain: IPR008289

Each member of this group contains five functional domains catalysing five sequential steps of the shikimate pathway. Each domain corresponds to a monofunctional prokaryotic enzyme of the same pathway: 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate 5-dehydrogenase, shikimate kinase, and 3-phosphoshikimate 1-carboxyvinyltransferase. The multifunctional gene is regulated in response to amino acid limitation by coordinate regulation, which provides an economical means of simultaneously synthesizing five shikimate pathway enzymes [ 1 ].

1. The Saccharomyces cerevisiae ARO1 gene. An example of the co-ordinate regulation of five enzymes on a single biosynthetic pathway. FEBS Lett. 241, 83-8