InterPro domain: IPR008179

Phosphoribosyl-ATP pyrophosphatase, 3.6.1.31 catalyses the second step in the histidine biosynthetic pathway [ 1 ]:

5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi

In E. coli, HisIE is encoded by the hisIE gene, which is formed by hisE gene fused to hisl [ 2 ]. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity, respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins, all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].

1. PHOSPHORIBOSYLADENOSINE MONOPHOSPHATE, AN INTERMEDIATE IN HISTIDINE BIOSYNTHESIS. J. Biol. Chem. 240, 3056-63
2. Cloning of the histidine biosynthetic genes from Corynebacterium glutamicum: organization and analysis of the hisG and hisE genes. Can. J. Microbiol. 46, 848-55
3. House cleaning, a part of good housekeeping. Mol. Microbiol. 59, 5-19
4. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. J. Mol. Biol. 347, 243-55
5. The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Acta Crystallogr. D Biol. Crystallogr. 64, 627-35
6. Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons. J. Mol. Biol. 203, 585-606
7. Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph. J. Bacteriol. 172, 3898-904
8. Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribosyl-AMP cyclohydrolase. Plant Physiol. 118, 275-83
9. Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region. Mol. Gen. Genet. 203, 382-8
10. Histidine biosynthesis genes in Lactococcus lactis subsp. lactis. J. Bacteriol. 174, 6571-9
11. Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene. Mol. Gen. Genet. 216, 224-9
12. Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2. J. Bacteriol. 179, 4429-32
13. Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene and a fragment of a PEX5-like gene from Candida albicans. Yeast 14, 1147-57
14. The nucleotide sequence of the HIS4 region of yeast. Gene 18, 47-59
15. Cloning and characterization of the multifunctional his-3 gene of Neurospora crassa. Gene 39, 129-40