InterPro domain: IPR008160
General Information
- Identifier IPR008160
- Description Collagen triple helix repeat
- Number of genes 25
- Gene duplication stats Loading...
Abstract
Members of this family belong to the collagen superfamily [ 1 ].Collagens are generally extracellular structural proteinsinvolved in formation of connective tissue structure.The sequence is predominantly repeats of the G-X-Y and the polypeptide chainsform a triple helix. The first position of the repeat isglycine, the second and third positions can be any residuebut are frequently proline and hydroxyproline. Collagensare post-translationally modified by proline hydroxylaseto form the hydroxyproline residues. Defectivehydroxylation is the cause of scurvy.
Some members of the collagen superfamily are not involvedin connective tissue structure but share the same triplehelical structure.
1. New members of the collagen superfamily. Curr. Opin. Cell Biol. 5, 883-90