InterPro domain: IPR008049

General Information

  • Identifier IPR008049
  • Description DNA replication licensing factor Mcm6

Abstract

In eukaryotes, Mcm6 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ 1 ]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [ 2 , 3 , 4 ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [ 5 ].

The components of the MCM2-7 complex are:

  • DNA replication licensing factor MCM2, IPR008045
  • DNA replication licensing factor MCM3, IPR008046
  • DNA replication licensing factor MCM4, IPR008047
  • DNA replication licensing factor MCM5, IPR008048
  • DNA replication licensing factor MCM6, IPR008049
  • DNA replication licensing factor MCM7, IPR008050


1. Structure and mechanism of helicases and nucleic acid translocases. Annu. Rev. Biochem. 76, 23-50
2. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 139, 719-30
3. A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc. Natl. Acad. Sci. U.S.A. 106, 20240-5
4. Control over DNA replication in time and space. FEBS Lett. 586, 2803-12

Species distribution

Gene table