InterPro domain: IPR008012

General Information

  • Identifier IPR008012
  • Description Proteasome maturation factor Ump1
  • Number of genes 178
  • Gene duplication stats Loading...
  • Associated GO terms GO:0043248  

Abstract

Ump1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Ump1 is required for the correct assembly and enzymatic activation of the proteasome. Ump1 seems to be degraded by the proteasome upon its formation [ 1 , 2 ].


1. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92, 489-99
2. beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J. 26, 2339-49

Species distribution

Gene table