InterPro domain: IPR007967

This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta [ 1 ]. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria [ 2 , 3 , 4 ].

1. GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. Biochemistry 45, 11379-89
2. Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Dis Model Mech 2, 490-9
3. The genetic control of plant mitochondrial morphology and dynamics. Plant J. 36, 500-9
4. The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution. J. Cell. Sci. 111 ( Pt 12), 1717-27