InterPro domain: IPR007918
General Information
- Identifier IPR007918
- Description Mitochondrial distribution/morphology family 35/apoptosis
- Number of genes 113
- Gene duplication stats Loading...
Abstract
This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) O60200 is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM) [ 1 ]; wherease in Homo sapiens (Human), p53CSV, O43715 is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including low-levels of DNA damage. It is suggested that p53CSV modulates the apoptotic pathway through interaction with HSP70 and Apaf-1 thereby inhibiting activation of procaspase-3 and procaspase-9 [ 2 ].
1. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell 13, 847-53
2. p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Cancer Res. 65, 1197-206