InterPro domain: IPR007817

Dit1 is involved in the synthesis of dityrosine [ 1 ]. Dityrosine is a sporulation-specific component of the Saccharomyces cerevisiae ascospore wall that is essential for the resistance of the spores to adverse environmental conditions. Q9I1L5 is involved in the biosynthesis of pyoverdine [ 2 ].

This entry also includes isocyanide synthases, which are required for the biosynthesis of isocyanides, a class of microbial secondary metabolites that can be cytotoxic, antibacterial, and antiprotozoal [ 3 ].

1. The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall. Proc. Natl. Acad. Sci. U.S.A. 91, 4524-8
2. Novel pyoverdine biosynthesis gene(s) of Pseudomonas aeruginosa PAO. Microbiology (Reading, Engl.) 142 ( Pt 5), 1181-90
3. Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. MBio 9