InterPro domain: IPR007727

This entry includes budding yeast Spo12 and its paralogue, Bns1, that arose from the whole genome duplication. Spo12 plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive [ 1 ]. Spo12 is a nuclear protein [ 2 ]. Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, which promotes Cdc14 release from the nucleolus during early anaphase [ 3 ]. The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12 [ 4 ].

1. The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex. Genetics 159, 965-80
2. Nuclear import of Spo12p, a protein essential for meiosis. J. Biol. Chem. 276, 17712-7
3. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108, 207-20