InterPro domain: IPR007704
General Information
- Identifier IPR007704
- Description GPI mannosyltransferase 1
- Number of genes 161
- Gene duplication stats Loading...
- Associated GO terms GO:0006506 GO:0051751 GO:0016021 GO:0004376
Abstract
PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilise nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates [ 1 ].
1. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. EMBO J. 20, 250-61
Species distribution
Gene table
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