InterPro domain: IPR007667

This domain is found in proteins thought to be involved in the response to hypoxia [ 1 ]. It is also found in altered inheritance of mitochondria proteins.

The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia induciblemitochondrial protein (HIMP1) is up-regulated by stresses of themicroenvironment such as low oxygen or low glucose conditions. HIG1 is amitochondrial inner membrane protein, which is ubiquitously expressed. It ispredicted to be an integral membrane protein consisting of two hydrophobichelices, 21-23 residues in length that might tend to form a hairpin-like loopacross the bilayer. HIG1 could be implied in apoptotic or cytoprotectivesignals. HIG1 is a member of a well conserved eukaryote protein family. Thepredicted transmembrane helice (TMH) and loop regions represent the mosthighly conserved regions in these proteins [ 2 , 3 ].The profile we developed covers the predicted TMH and loop regions.

1. Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis. Proc. Natl. Acad. Sci. U.S.A. 98, 1993-8
2. Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression. Int. J. Dev. Biol. 49, 431-6
3. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc. Natl. Acad. Sci. U.S.A. 103, 10636-41