InterPro domain: IPR007621

TPM domain is named after its founding proteins: TLP18.3, Psb32 and MOLO-1.

In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold [ 1 ]. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II [ 2 , 3 ].

In C. elegans, the MOLO-1 protein is an auxiliary subunit that positively modulates the gating of levamisole-sensitive acetylcholine receptors [ 4 ].

1. Structural and Functional Assays of AtTLP18.3 Identify Its Novel Acid Phosphatase Activity in Thylakoid Lumen. Plant Physiol. 157, 1015-25
2. TLP18.3, a novel thylakoid lumen protein regulating photosystem II repair cycle. Biochem. J. 406, 415-25
3. The Psb32 protein aids in repairing photodamaged photosystem II in the cyanobacterium Synechocystis 6803. Mol Plant 4, 1052-61
4. Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit. Nat. Neurosci. 15, 1374-81