InterPro domain: IPR007594
General Information
- Identifier IPR007594
- Description RFT1
- Number of genes 156
- Gene duplication stats Loading...
- Associated GO terms GO:0016021 GO:0006488
Abstract
Asymmetric lipid distribution is a fundamental characteristic of biological lipid bilayers, one such axample is the translocation of the Man 5 GlcNAc 2 -PP-Dol intermediate from the cytosolic side of the ER membrane to the lumen before the completion of the biosynthesis of Glc 3 Man 9 GlcNAc 2 -PP-Dol [ 1 ]. RFT1 encodes an evolutionarily conserved protein required for this translocation.
1. Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415, 447-50
Species distribution
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