InterPro domain: IPR007587

General Information

  • Identifier IPR007587
  • Description SIT4 phosphatase-associated protein family
  • Number of genes 428
  • Gene duplication stats Loading...
  • Associated GO terms GO:0019903   GO:0043666  

Abstract

This entry includes budding yeast Sit4-associated proteins, such as Sap155, Sap185, and Sap190. Sit4 is a phosphatase involved in a variety of processes including transcription, translation, bud formation, glycogen metabolism, monovalent ion homeostasis, H+ transport, and telomere function [ 1 ].

This entry also includes mammalian PP6 (Sit4 homologue)-associated proteins, such as PP6R1, PP6R2, and PP6R3 [ 2 ]. They are regulatory subunits of PP6 involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha [ 2 ].


1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. J. Biol. Chem. 281, 22624-34

Species distribution

Gene table