InterPro domain: IPR007371

General Information

  • Identifier IPR007371
  • Description Thiamin pyrophosphokinase, catalytic domain

Abstract

Thiamin pyrophosphokinase (TPK, 2.7.6.2 ) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggests that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [ 1 ].


1. The crystal structure of yeast thiamin pyrophosphokinase. Structure 9, 539-46

Species distribution

Gene table