InterPro domain: IPR007346
General Information
- Identifier IPR007346
- Description Endonuclease I
- Number of genes 66
- Gene duplication stats Loading...
- Associated GO terms GO:0004518
Abstract
Bacterial periplasmic or secreted ( 3.1.21.1 ) Escherichia coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species. It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown [ 1 ]. Other family members are known to be extracellular [ 2 ]. This family also includes a non-specific, Mg 2+ -activated ribonuclease precursor ( Q03091 ) [ 3 ].
1. The periplasmic endonuclease I of Escherichia coli has amino-acid sequence homology to the extracellular DNases of Vibrio cholerae and Aeromonas hydrophila. Gene 154, 55-9
2. Extracellular proteins of Vibrio cholerae: molecular cloning, nucleotide sequence and characterization of the deoxyribonuclease (DNase) together with its periplasmic localization in Escherichia coli K-12. Gene 53, 31-40
3. Gene cloning and characterization of a novel extracellular ribonuclease of Bacillus subtilis. Eur. J. Biochem. 209, 121-7