InterPro domain: IPR007315
General Information
- Identifier IPR007315
- Description GPI mannosyltransferase 2
- Number of genes 166
- Gene duplication stats Loading...
- Associated GO terms GO:0006506 GO:0000009 GO:0004376
Abstract
This entry represents GPI mannosyltransferase 2, also known as PIG-V in humans or Gpi18 in fungi. PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol (GPI) biosynthesis [ 1 , 2 , 3 ]. GPI is a glycolipid that anchors many proteins to the eukaryotic cell surface [ 4 ].
1. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. J. Biol. Chem. 280, 9489-97
2. Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. FEBS J. 272, 1160-8
3. Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae. Mol. Biol. Cell 18, 3472-85