InterPro domain: IPR007306

This entry includes tRNA A64-2'-O-ribosylphosphate transferase Rit1 from budding yeasts. Rit1 is a phospho-ribosyl transferase that exclusively modifies the initiator tRNA (tRNAMet(i)) by the addition of a 2'-O-ribosyl phosphate group to Adenosine 64 [ 1 , 2 ]. This entry also includes the C3F10.06c protein from Schizosaccharomyces pombe.

1. Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. Cell 79, 535-46
2. Genetic interactions between a null allele of the RIT1 gene encoding an initiator tRNA-specific modification enzyme and genes encoding translation factors in Saccharomyces cerevisiae. Mol. Gen. Genet. 261, 967-76