InterPro domain: IPR007304
General Information
- Identifier IPR007304
- Description TAP46-like protein
- Number of genes 161
- Gene duplication stats Loading...
- Associated GO terms GO:0009966
Abstract
The TOR signalling pathway activates a cell-growth program in response to nutrients [ 1 ]. TIP41 interacts with TAP42 and negatively regulates the TOR signalling pathway [ 2 ].
This entry represents a family of proteins involved in the regulation of phosphatases. It includes TAP46 and TAP42, as well as others.
TAP46 is involved in the positive regulation of the TOR signaling pathway in plants, acting as a negative regulator of PP2A catalytic activity [ 3 ].
1. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402, 689-92
2. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell 8, 1017-26
3. The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Plant Cell 23, 185-209