InterPro domain: IPR007282

General Information

  • Identifier IPR007282
  • Description NOT2/NOT3/NOT5, C-terminal
  • Number of genes 393
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006355  

Abstract

NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes [ 1 ]. This domain can be found in NOT2, NOT3 and NOT5.


1. NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 8, 525-37

Species distribution

Gene table