InterPro domain: IPR007262

This entry includes Vps55 from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals. Both Vps55 and OB-RGRP are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [ 1 ].

Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase [ 2 ].

The leptin receptor overlapping transcript (LEPROT) is co-transcribed with Leptin receptor (LepR) but without similarity to the LepR. Mammals have a single LEPROT homologue called LEPROT like-1 (LEPROTL1), which is also included in this entry. LepROT plays roles in insulin pathway [ 2 ]. LEPROT and LEPROTL1 have also been shown to influence liver growth hormone signaling in mice [ 3 ].

1. Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking. Mol. Biol. Cell 13, 1694-708
2. Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO. Gene 587, 64-9
3. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J. Clin. Invest. 119, 3830-8