InterPro domain: IPR007248

The 22kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by specific targeting information [ 1 ]. Mpv17 is a closely related peroxisomal protein involved in the development of early-onset glomerulosclerosis [ 2 ].

A member of this family found in Saccharomyces cerevisiae (Baker's yeast) is an integral membrane protein of the inner mitochondrial membrane and has been suggested to play a role in mitochondrial function during heat shock [ 3 ].

1. Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes. J. Biol. Chem. 277, 774-84
2. Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family. Biochem. Biophys. Res. Commun. 283, 292-6
3. SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mammalian kidney disease gene Mpv17 and is required for ethanol metabolism and tolerance during heat shock. Eukaryotic Cell 3, 620-31