InterPro domain: IPR007229

Nicotinate phosphoribosyltransferase ( 2.4.2.11 ) is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis [ 1 ]. Members in this family can be split into two further subfamilies represented in IPR006405 and IPR006406 . Members in IPR006405 have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. However, one argument suggesting that this family represents the same enzyme is that no species has a member of both subfamilies. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria.

1. Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J. Biol. Chem. 283, 19329-41