InterPro domain: IPR007209

This is part of a possible metal-binding domain in endoribonuclease RNase L inhibitor. It is found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, IPR017896 . Also often found adjacent to IPR007177 in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [ 1 ]. It is a component of the multifactor complex (MFC) involved in translation initiation and it is required for the processing and nuclear export of the 60S and 40S ribosomal subunits, playing a role in ribosome biogenesis [ 2 , 3 . Inhibitory activity requires concentration-dependent association of RLI with RNase L [ 4 ].

1. cDNA cloning and expression analysis of the murine ribonuclease L inhibitor. Gene 209, 149-56
2. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem 279, 42157-68
3. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 24, 580-8
4. Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270, 13308-17