InterPro domain: IPR007157

In Gram-negative organisms, PspA is part of the multi-gene Phage shock protein (Psp) response system that mitigates envelope damage by preventing proton leakage across a damaged membrane, thereby maintaining proton motive force [ 1 ]. In Mycobacterium tuberculosis, PspA has been shown to integrate envelope stress-sensing and envelope-preserving functions [ 2 ]. It also regulates lipid droplet homeostasis and nonreplicating persistence (NRP) in M. tuberculosis [ 2 ]. The PspA homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis [ 3 ].

1. The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions. Mol. Microbiol. 97, 408-22
2. Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis. J. Bacteriol. 198, 1645-1661
3. Mechanism of action of the Escherichia coli phage shock protein PspA in repression of the AAA family transcription factor PspF. J. Mol. Biol. 320, 23-37