InterPro domain: IPR007111
General Information
- Identifier IPR007111
- Description NACHT nucleoside triphosphatase
- Number of genes 9
- Gene duplication stats Loading...
Abstract
The NACHT domain is a 300 to 400 residue predicted nucleoside triphosphatase (NTPase) domain, which is found in animal, fungal and bacterial proteins. The NACHT domain has been named after NAIP, CIITA, HET-E and TP1. It is found inassociation with other domains, such as the CARD domain ( IPR001315 ), theDAPIN domain ( IPR004020 ), the HEAT repeat ( IPR004155 ), the WDrepeat ( IPR001680 ), the leucine-rich repeat (LRR) or the BIR repeat ( IPR001370 ) [ 1 ].
The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg(2+)-binding site (WalkerA and B motifs, respectively) and five more specific motifs. The unique features of the NACHT domain include the prevalence of 'tiny' residues(glycine, alanine or serine) directly C-terminal of the Mg(2+)-coordinating aspartate in the Walker B motif, in place of a second acidic residue prevalentin other NTPases. A second acidic residue is typically found in the NACHT-containing proteins two positions downstream. Furthermore, the distal motif VII contains a conserved pattern of polar, aromatic and hydrophobic residues that is not seen in any other NTPase family [ 2 ].
1. The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem. Sci. 25, 223-4