InterPro domain: IPR007081

General Information

  • Identifier IPR007081
  • Description RNA polymerase Rpb1, domain 5

Abstract

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to form the central cleft or channel where the DNA is bound [ 1 , 2 ].


1. Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 271, 27969-74
2. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 292, 1863-76

Species distribution

Gene table