InterPro domain: IPR007080
General Information
- Identifier IPR007080
- Description RNA polymerase Rpb1, domain 1
- Number of genes 804
- Gene duplication stats Loading...
- Associated GO terms GO:0003677 GO:0003899 GO:0006351
Abstract
RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 1, represents the clamp domain, which is a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [ 1 , 2 , 3 ].
1. Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 271, 27969-74
2. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 292, 1863-76
3. RNA polymerase I structure and transcription regulation. Nature 502, 650-5