InterPro domain: IPR007066
General Information
- Identifier IPR007066
- Description RNA polymerase Rpb1, domain 3
- Number of genes 681
- Gene duplication stats Loading...
- Associated GO terms GO:0003677 GO:0003899 GO:0006351
Abstract
RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [ 1 , 2 , 3 ].
1. Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 271, 27969-74
2. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 292, 1863-76
3. RNA polymerase I structure and transcription regulation. Nature 502, 650-5