InterPro domain: IPR007024
General Information
- Identifier IPR007024
- Description BLUF domain
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0071949 GO:0009882
Abstract
The BLUF domain (named for sensors of Blue-Light Using FAD) is an FAD-binding protein domain. BLUF domains are present in various proteins, primarily from bacteria. For example a BLUF domain is found at the N terminus of the AppA protein from Rhodobacter sphaeroides [ 1 ]. BLUF domains are involved in sensing blue-light (and possibly redox) using FAD, and are similar to the flavin-binding PAS domains and cryptochromes. Their predicted secondary structure reveals that the BLUF domains have a novel FAD-binding fold [ 2 ].
1. The solution structure of the AppA BLUF domain: insight into the mechanism of light-induced signaling. Chembiochem 7, 187-93
2. BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms. Trends Biochem. Sci. 27, 497-500